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Article

Transient dynamics of Aβ contribute to toxicity in Alzheimer’s disease

6 May 2014

Abstract excerpt

The aggregation and deposition of the amyloid-β peptide (Aβ) in the brain has been linked with neuronal death, which progresses in the diagnostic and pathological signs of Alzheimer's disease (AD). The transition of an unstructured monomeric peptide into self-assembled and more structured aggregates is the crucial conversion from what appears to be a harmless polypeptide into a malignant form that causes...

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PMID: 24803005
DOI: 10.1007/s00018-014-1634-z

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