Article

Intrinsic T-cell programming and immune spatial organization govern sex-biased tuberculosis immunity

2026-07-11

Abstract excerpt

Biological sex can profoundly influence the susceptibility to infectious diseases, yet the mechanisms behind the sex-dependent protective immunity against tuberculosis (TB) remain poorly understood. Here we show that sexually divergent immunity during chronic Mycobacterium tuberculosis (Mtb) infection is governed by both intrinsic T cell programming and pulmonary immune spatial organization. Using the Four Core G...

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Literature Corpus work: c17e5728-9e19-5a0a-bdbb-a1e147b0496e
DOI: 10.64898/2026.07.07.737119

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