Article

Gonadal regulation of sex-specific immunity in tuberculosis: enhanced lymphocyte function in females and dysfunctional myeloid responses in males

2026-06-12

Abstract excerpt

Tuberculosis (TB), the world’s deadliest infection, shows higher prevalence and mortality in males than females (M/F ratio >1.7). Using Four Core Genotype (FCG) mice to decouple gonadal from chromosomal sex (XX, XY gonadal males and XX, XY gonadal females), we show that gonadal males develop accelerated disease driven by dysfunctional myeloid responses rather than impaired bacterial recognition. Both XX and XY mal...

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Literature Corpus work: c4178045-dc46-5c4f-973b-4395fe0025de
DOI: 10.64898/2026.06.11.731661

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