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Article

B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles.

Communications biology - 16 May 2024

Krause Robert, Ogongo Paul, Tezera Liku, Ahmed Mohammed, Mbano Ian, Chambers Mark, Ngoepe Abigail, Magnoumba Magalli, Muema Daniel, Karim Farina, Khan Khadija, Lumamba Kapongo, Nargan Kievershen, Madansein Rajhmun, Steyn Adrie, Shalek Alex K, Elkington Paul, Leslie Al

Abstract excerpt

B cells are important in tuberculosis (TB) immunity, but their role in the human lung is understudied. Here, we characterize B cells from lung tissue and matched blood of patients with TB and found they are decreased in the blood and increased in the lungs, consistent with recruitment to infected tissue, where they are located in granuloma associated lymphoid tissue. Flow cytometry and transcriptomics identify...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 38755239
DOI: 10.1038/s42003-024-06282-7
PMCID: PMC11099031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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