Article

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity

2025-04-01

Abstract excerpt

Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB disease that occur in humans and allows identification of genomic loci underlying clinical outcomes. We previously mapped a TB susceptibility locus on mouse chromoso...

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Identifiers and source

Literature Corpus work: 447596a3-7004-504f-9352-e84dece57793
DOI: 10.1101/2025.04.01.644622

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