Article

Human in vivo immunology of tuberculosis is not affected by sex dimorphism

2026-07-21

Abstract excerpt

Males incur greater risk of tuberculosis (TB) than females, but the contribution of sex-associated immune differences remains unclear. We addressed this using sex-stratified transcriptomic analyses across four independent studies spanning active pulmonary TB, subclinical TB and latent infection, in peripheral blood, bronchoalveolar lavage (BAL) and by using the tuberculin skin test (TST) as a standardised in vivo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3908c829-5972-5ed5-b2e2-08763c4aa02f
DOI: 10.64898/2026.07.20.26358462

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human in vivo immunology of tuberculosis is not affected by sex dimorphismDOI 10.64898/2026.07.20.26358462Read

Single‐Cell Sequencing Reveals Functional Alterations in TuberculosisSemantic proximity Read

Host- and pathogen-related determinants of pulmonary versus extrapulmonary tuberculosis.Semantic proximity Read

Lung Resident T Cells Across the Spectrum of TB Infection and DiseaseSemantic proximity Read

Transcriptomic profiling identifies breed-specific immune signatures of Tuberculosis susceptibility in cattleSemantic proximity Read

Immune endotypes in tuberculosis: Keys to decoding disease complexity.Semantic proximity Read

Beyond the Clinic: The Activation of Diverse Cellular and Humoral Factors Shapes the Immunological Status of Patients with Active TuberculosisSemantic proximity Read

Single-cell transcriptome sequencing reveals altered peripheral blood immune cells in patients with severe tuberculosisSemantic proximity Read

Gonadal regulation of sex-specific immunity in tuberculosis: enhanced lymphocyte function in females and dysfunctional myeloid responses in malesSemantic proximity Read

Tuberculosis and sexual inequality: the role of sex hormones in immunity.Semantic proximity Read

Comparative transcriptomic analysis of whole blood mycobacterial growth assays and tuberculosis patients’ blood RNA profilesSemantic proximity Read

Sex differences in vaccine induced immunity and protection against <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependentSemantic proximity Read