Article

Red Blood Cell Triphenotype Classification (RTC): A Functional Framework Integrating Glucose Sink Capacity, Oxygen Kinetics, and Antioxidant Reserve

2026-07-07

Abstract excerpt

Erythrocytes are routinely characterized in clinical medicine by three twentieth-century parameters: haemoglobin concentration, haematocrit, and mean corpuscular volume. This framework reflects an outdated view of the red cell as a passive oxygen carrier. Recent landmark findings—including the 2026 demonstration that erythrocytes function as a primary glucose sink during chronic hypoxia, the 2021 elucidation of th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c175601e-157b-5fb8-be78-25141e5e7677
DOI: 10.20944/preprints202607.0443.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Red Blood Cell Triphenotype Classification (RTC): A Functional Framework Integrating Glucose Sink Capacity, Oxygen Kinetics, and Antioxidant ReserveDOI 10.20944/preprints202607.0443.v1Read

The Hyperoxia Paradox: The Missing Red Blood Cell Axis in Stress HyperglycaemiaSemantic proximity Read

A population-scale Red Blood Cell proteome atlas of 13,000 donors uncovers genetically encoded aging clocks predicting hemolysis, transfusion efficacy, and donor activity a decade laterSemantic proximity Read

The Neonatal Red-Cell Compartment as an Overlooked Glucose Sink: A Dual-Axis Hypothesis Linking Developmental Erythrocyte Biology to Neonatal HypoglycaemiaSemantic proximity Read

HbA1c Reconsidered: Glycated Haemoglobin in the Era of Dynamic Erythrocyte Glucose MetabolismSemantic proximity Read

Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent <i>S</i> -Nitroso TransferSemantic proximity Read

The Perpetual Erythrocyte Cohort Churning Hypothesis: A Unifying Mechanism for Cardiovascular and Neurodegenerative Risk in Obstructive Sleep ApnoeaSemantic proximity Read

Genetic variation of human G6PD impacts Red Blood Cell transfusion efficacySemantic proximity Read

Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion OutcomesSemantic proximity Read

Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitudeSemantic proximity Read

Ferroptosis regulates hemolysis in stored murine and human red blood cellsSemantic proximity Read

Proteomic analysis of red blood cells and the potential for the clinic: what have we learned so far?Semantic proximity Read

Arginine metabolism is a biomarker of red blood cell and human agingSemantic proximity Read