Article

The Perpetual Erythrocyte Cohort Churning Hypothesis: A Unifying Mechanism for Cardiovascular and Neurodegenerative Risk in Obstructive Sleep Apnoea

2026-07-09

Abstract excerpt

Obstructive sleep apnoea (OSA) is associated with substantially elevated cardiovascular, neurodegenerative, and metabolic morbidity, yet the mechanistic chain linking nocturnal intermittent hypoxia to these clinical consequences remains incompletely understood. We highlight three apparent contradictions in the existing OSA erythrocyte literature: (i) accelerated erythropoiesis with normal haemoglobin concentration...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 87b17857-48c8-59af-b4be-196ff30a5404
DOI: 10.20944/preprints202607.0622.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Perpetual Erythrocyte Cohort Churning Hypothesis: A Unifying Mechanism for Cardiovascular and Neurodegenerative Risk in Obstructive Sleep ApnoeaDOI 10.20944/preprints202607.0622.v1Read

Red Blood Cell Triphenotype Classification (RTC): A Functional Framework Integrating Glucose Sink Capacity, Oxygen Kinetics, and Antioxidant ReserveSemantic proximity Read

Sickle cell disease-associated pulmonary hypertension: an integrated framework linking pathologies, mechanisms, and clinical phenotypes.Semantic proximity Read

Nationwide real-world cohort of paroxysmal nocturnal hemoglobinuria in ChileSemantic proximity Read

A population-scale Red Blood Cell proteome atlas of 13,000 donors uncovers genetically encoded aging clocks predicting hemolysis, transfusion efficacy, and donor activity a decade laterSemantic proximity Read

The comorbidity burden and disease phenotype in pre-capillary pulmonary hypertension: The contributing role of obstructive sleep apnea.Semantic proximity Read

Longevity Humans Have Youthful Erythrocyte Function and Metabolic SignaturesSemantic proximity Read

The circulatory physiopathology of human red blood cells investigated with a multiplatform model of cellular homeostasis. III. Senescence changes during the full circulatory lifespanSemantic proximity Read

Arginine metabolism is a biomarker of red blood cell and human agingSemantic proximity Read

HbA1c Reconsidered: Glycated Haemoglobin in the Era of Dynamic Erythrocyte Glucose MetabolismSemantic proximity Read

The cellular pathogenesis of paroxysmal nocturnal haemoglobinuriaSemantic proximity Read

Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent <i>S</i> -Nitroso TransferSemantic proximity Read

To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes.Semantic proximity Read