Article

Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes

2023-09-11

Abstract excerpt

<h4>Summary</h4> Mature red blood cells (RBCs) lack mitochondria, and thus exclusively rely on glycolysis to generate adenosine triphosphate (ATP) during aging in vivo or storage in the blood bank. Here we leveraged 13,029 volunteers from the Recipient Epidemiology and Donor Evaluation Study to identify an association between end-of-storage levels of glycolytic metabolites and donor age, sex, and ancestry-specifi...

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Literature Corpus work: 072898b2-8df8-58a4-8cfc-f49b32fc5343
DOI: 10.1101/2023.09.11.557250

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Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion OutcomesDOI 10.1101/2023.09.11.557250Read

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