Article

The Hyperoxia Paradox: The Missing Red Blood Cell Axis in Stress Hyperglycaemia

2026-07-15

Abstract excerpt

Stress hyperglycaemia affects more than half of critically ill patients within 48 hours of admission and predicts adverse outcomes. The classical mechanistic model attributes this phenomenon entirely to counter-regulatory hormones, inflammatory cytokines, and peripheral insulin resistance. Recent demonstration that red blood cells (RBCs) function as a primary glucose sink under chronic hypoxia, capable of redirect...

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Literature Corpus work: f2dcd585-345b-570c-90e5-ef40ce60a7ea
DOI: 10.20944/preprints202607.1077.v1

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