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HbA1c Reconsidered: Glycated Haemoglobin in the Era of Dynamic Erythrocyte Glucose Metabolism

2026-07-13

Abstract excerpt

Glycated haemoglobin (HbA1c) has served for four decades as the standard biomarker for long-term glycaemic control, with global use approaching one billion measurements annually. The biomarker rests on a tacit assumption: that the rate of non-enzymatic haemoglobin glycation is determined chiefly by mean plasma glucose concentration, with erythrocyte intracellular glucose acting as a passive equilibrium with plasma...

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Literature Corpus work
e30b2148-2d36-57f9-9e5b-5feee968d329
DOI
10.20944/preprints202607.0826.v1
Open publication

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HbA1c Reconsidered: Glycated Haemoglobin in the Era of Dynamic Erythrocyte Glucose MetabolismDOI 10.20944/preprints202607.0826.v1
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