Article

Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent <i>S</i> -Nitroso Transfer

2025-11-30

Abstract excerpt

Red blood cells (RBCs) have long been regarded as passive oxygen carriers, yet growing evidence reveals a complex, dynamic proteome independent of de novo gene expression. Here, we define the erythrocyte as an oxygen-responsive system organized around a Band 3 (SLC4A1)–centered metabolon. Using deep proteomics of ultra-pure RBCs and cross-linking interactomics, we identify biliverdin reductase B (BLVRB) as a previ...

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Literature Corpus work: 4d5863b7-462f-5e25-89ba-3318e0e37f10
DOI: 10.1101/2025.11.29.691178

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