Article

Shared genetic architecture between major depressive disorder and four digestive diseases in European populations

2026-08-30

Abstract excerpt

Patients diagnosed with cholelithiasis, gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), and constipation frequently exhibit comorbid major depressive disorder (MDD). Although the underlying mechanisms remain elusive, potential genetic associations have been proposed. Leveraging extensive genome-wide association study databases, the genetic association patterns between MDD and four digestive...

Identifiers and source

Literature Corpus work: c137740c-1924-5b84-8cda-6d0056f1b079
DOI: 10.1186/s12991-026-00695-w

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Shared genetic architecture between major depressive disorder and four digestive diseases in European populationsDOI 10.1186/s12991-026-00695-wRead

Shared genetic architecture between major depressive disorder and inflammatory bowel disease: Insights from large-scale genome-wide cross-trait analysis.Semantic proximity Read

Dissecting Pleiotropy Between Major Depressive Disorder and Physical Disease ComorbiditiesSemantic proximity Read

Dissecting pleiotropy between major depressive disorder and physical disease comorbidities.Semantic proximity Read

Identification of overlapping genetic loci between inflammatory bowel disease and major depressive disorder.Semantic proximity Read

Investigating the Causal Relationship and Shared Genetic Basis Between Major Depression Disorder and Eight Types of Gastrointestinal Diseases.Semantic proximity Read

Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases.Semantic proximity Read

Shared genetic susceptibilities for irritable bowel syndrome and depressive disorder in Chinese patients uncovered by pooled whole-exome sequencingSemantic proximity Read

Genetic Association Analysis Between Depression and Gastroesophageal Reflux Disease- Related PhenotypesSemantic proximity Read

Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disordersSemantic proximity Read

Exploring the shared genetic basis of major depressive disorder and frailty.Semantic proximity Read

Genetic correlation, pleiotropic loci and shared risk genes between major depressive disorder and gastrointestinal tract disordersSemantic proximity Read

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbiditiesSemantic proximity Read