Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting pleiotropy between major depressive disorder and physical disease comorbidities.

Nature genetics - 1 Sept 2026

Woodward Damian J, Reay William R, Wormington Briar, Diaz-Torres Santiago, Ong Jue-Sheng, Gerring Zachary F, Thorp Jackson G, Derks Eske M

Abstract excerpt

Major depressive disorder (MDD) is characterized by substantial comorbidity with medical conditions. To achieve better outcomes for patients with MDD, an improved understanding of the mechanisms underlying pervasive comorbidities is required. Here, to this end, we mapped patterns of pleiotropy by defining four clusters of physical diseases (cardiovascular, metabolic, gastrointestinal and immune) and analyzed...

Read the complete abstract on PubMed

Topics

Major Depressive Disorder
Humans
Genetic Pleiotropy
Comorbidity
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Gastrointestinal Diseases

Cardiovascular Diseases

Metabolic Diseases

Immune System Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 42649390
DOI: 10.1038/s41588-026-02735-3
PMCID: PMC13553304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting pleiotropy between major depressive disorder and physical disease comorbidities.PMID 42649390Read ↗

Dissecting Pleiotropy Between Major Depressive Disorder and Physical Disease ComorbiditiesSemantic proximity Read ↗

Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases.Semantic proximity Read ↗

Shared genetic architecture between major depressive disorder and four digestive diseases in European populationsSemantic proximity Read ↗

Shared genetic architecture between major depressive disorder and inflammatory bowel disease: Insights from large-scale genome-wide cross-trait analysis.Semantic proximity Read ↗

Phenomic Network Analysis for Depression Reveals Comorbidity Architecture, Genomic Relationships, and Pleiotropic VariantsSemantic proximity Read ↗

Genetic heterogeneity affects the risk of incident depression, comorbidity, and response to environment: A prospective trajectory study.Semantic proximity Read ↗

Overlapping common genetic architecture between major depressive disorders and anxiety and stress-related disorders.Semantic proximity Read ↗

Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular diseaseSemantic proximity Read ↗

Differential associations of various depression-related phenotypes with cardiometabolic risks: Identification of shared genetic factors and implications for drug repositioningSemantic proximity Read ↗

Genetic correlation, pleiotropic loci and shared risk genes between major depressive disorder and gastrointestinal tract disordersSemantic proximity Read ↗

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease.Semantic proximity Read ↗

Symptom-specific genetics reveal heterogeneity within major depressive disorderSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.