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Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases.

Translational psychiatry - 27 Dec 2024

Sun Wenxi, Baranova Ancha, Liu Dongming, Cao Hongbao, Zhang Xiaobin, Zhang Fuquan

Abstract excerpt

The high comorbidity of major depressive disorder (MDD) with other diseases has been well-documented. However, the pairwise causal connections for MDD comorbid networks are poorly characterized. We performed Phenome-wide Mendelian randomization (MR) analyses to explore bidirectional causal associations between MDD (N = 807,553) and 877 common diseases from FinnGen datasets (N = 377,277). The inverse variance...

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Comorbidity
Depressive Disorder, Major
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis

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PMID: 39730323
DOI: 10.1038/s41398-024-03216-z
PMCID: PMC11680865

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