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Identification of overlapping genetic loci between inflammatory bowel disease and major depressive disorder.

European archives of psychiatry and clinical neuroscience - 1 Feb 2026

Chang Shuangqing, Luo Qinghua

Abstract excerpt

BACKGROUND: Patients diagnosed with inflammatory bowel disease (IBD) are often observed to suffer from co-occurring major depressive disorder (MDD). Although the precise mechanisms remain elusive, there is a possibility of a genetic overlap between these conditions. METHODS: Genome-wide association study data collected from two IBD cohorts alongside one MDD cohort were analyzed. Initially, linkage disequilibrium...

Topics

Humans
Major Depressive Disorder
Genome-Wide Association Study
Inflammatory Bowel Diseases
Genetic Predisposition to Disease
Genetic Loci
Female
Polymorphism, Single Nucleotide
Male
Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40539999
DOI: 10.1007/s00406-025-02047-3

Genes

CCSER1
CRB1
MED24
P4HA2
RASGRP1
RBMS1
TCF4
ZNF365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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