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Article

Identification of overlapping genetic loci between inflammatory bowel disease and major depressive disorder.

European archives of psychiatry and clinical neuroscience - 1 Feb 2026

Chang Shuangqing, Luo Qinghua

Abstract excerpt

BACKGROUND: Patients diagnosed with inflammatory bowel disease (IBD) are often observed to suffer from co-occurring major depressive disorder (MDD). Although the precise mechanisms remain elusive, there is a possibility of a genetic overlap between these conditions. METHODS: Genome-wide association study data collected from two IBD cohorts alongside one MDD cohort were analyzed. Initially, linkage disequilibrium...

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Source

Identifiers

PMID: 40539999
DOI: 10.1007/s00406-025-02047-3

Genes

CCSER1
CRB1
MED24
P4HA2
RASGRP1
RBMS1
TCF4
ZNF365

Provenance

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