Article

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbidities

2022-08-25

Abstract excerpt

Major depression (MD) is a common mental disorder and a leading cause of disability worldwide. We conducted a GWAS meta-analysis of more than 1.3 million individuals, including 371,184 with MD, identifying 243 risk loci. Sixty-four loci are novel, including glutamate and GABA receptors that are targets for antidepressant drugs. Several biological pathways and components were enriched for genetic MD risk, implicati...

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Literature Corpus work: 4164a6dd-65ba-5ff5-9c7e-ae36726e9ed6
DOI: 10.1101/2022.08.24.22279149

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