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Article

Investigating the Causal Relationship and Shared Genetic Basis Between Major Depression Disorder and Eight Types of Gastrointestinal Diseases.

Genetics research - 1 Jan 2025

Sun Fu, Li Haochang, Gong Bin, Hui Shirong, He Ran, Yu Meijie, Li Yihao, Yang Sheng, Huang Peng

Abstract excerpt

Background: Previous studies on the causal relationship or shared genetic basis between major depression disorder (MDD) and gastrointestinal (GI) diseases covered either a limited range and not comprehensive enough. Methods: We used linkage disequilibrium score regression (LDSC) to estimate the heritability for nine traits and the genetic correlation (r g ) between MDD and eight GI diseases, respectively. We...

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Source

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Identifiers

PMID: 41438618
DOI: 10.1155/genr/6931243
PMCID: PMC12721742

Genes

PRSS16
C4A
FLOT1
MICB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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