Article

Dissecting Pleiotropy Between Major Depressive Disorder and Physical Disease Comorbidities

2025-10-15

Abstract excerpt

Major Depressive Disorder (MDD) is characterised by substantial comorbidity with medical conditions. To achieve better outcomes for patients with MDD, an improved understanding of the mechanisms underlying pervasive comorbidities is required. To this end, we map patterns of pleiotropy by defining four clusters of physical diseases (cardiovascular, metabolic, gastrointestinal, and immune) to analyse their genetic r...

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Literature Corpus work: f1d49771-7b6b-5873-94ad-4ac7526400b7
DOI: 10.1101/2025.10.14.25337939

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