Article

Topology-Resolved Imaging of Mitochondrial Nucleoid Condensates Uncovers Dynamic G-Quadruplex Remodeling

2026-04-01

Abstract excerpt

<title>Abstract</title> <p>G-quadruplex structures in mitochondrial DNA (mtG4DNA) have been implicated in mitochondrial genome regulation and cellular metabolism, yet their spatial organization within mitochondrial nucleoids remains poorly understood. A central challenge is that mtG4DNA cannot be readily distinguished from mitochondrial double-stranded DNA (mt-dsDNA) in living cells, which has limited direct anal...

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Literature Corpus work: c136537a-3643-5d1b-930e-b4fd1eb3bbb8
DOI: 10.21203/rs.3.rs-9241346/v1

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