Article

<i>OPA1</i> and disease-causing mutants perturb mitochondrial nucleoid distribution

2024-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Optic atrophy protein 1 (OPA1) mediates inner mitochondrial membrane (IMM) fusion and cristae organization. Mutations in OPA1 cause autosomal dominant optic atrophy (ADOA), a leading cause of blindness. Cells from ADOA patients show impaired mitochondrial fusion, cristae structure, bioenergetic function, and mitochondrial DNA (mtDNA) integrity. The mtDNA encodes electron transport chain subunits...

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Literature Corpus work: 0986bbaf-4f9b-55c5-b041-20ab5685f005
DOI: 10.1101/2024.02.01.578418

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