Article

Mitochondrial DNA Density Homeostasis Accounts for the Threshold Effect in Human Mitochondrial Disease

2016-09-30

Abstract excerpt

Mitochondrial dysfunction is involved in a wide array of devastating diseases but the heterogeneity and complexity of these diseases’ symptoms challenges theoretical understanding of their causation. With the explosion of -omics data, we have the unprecedented ability to gain deep understanding of the biochemical mechanisms of mitochondrial dysfunction. However, there is also a need to make such datasets interpret...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 310ad431-299f-5563-a770-e9e3ff00e165
DOI: 10.1101/078519

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial DNA Density Homeostasis Accounts for the Threshold Effect in Human Mitochondrial DiseaseDOI 10.1101/078519Read

Mitochondrial DNA density homeostasis accounts for a threshold effect in a cybrid model of a human mitochondrial disease.Semantic proximity Read

Stochastic modelling and inference for mitochondria in health and diseaseSemantic proximity Read

Mitochondrial network state scales mtDNA genetic dynamicsSemantic proximity Read

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial DiseasesSemantic proximity Read

Energetic costs of cellular and therapeutic control of stochastic mtDNA populationsSemantic proximity Read

Single-cell multi-omics resolved analysis of mitochondrial genome-wide mutational burden, constraint, and mosaicismSemantic proximity Read

Mass Control Genes Buffer a Conserved Sublinear Scaling Law Linking Single-Cell Dry Mass to Mitochondrial Redox EfficiencySemantic proximity Read

Single-cell multi-omic analysis of mitochondrial mutational mosaicism and dynamics.Semantic proximity Read

Identification and small molecule rescue of mitochondrial dysfunction phenotype which converges across Leigh Syndrome and Huntington’s Disease patient fibroblastsSemantic proximity Read

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.Semantic proximity Read

Mitochondrial dynamics in disease.Semantic proximity Read

MitoPerturb-Seq identifies common and gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmySemantic proximity Read