Article

TFAM organizes DNA into compact higher order structures

2026-04-27

Abstract excerpt

TFAM (Transcription Factor A, Mitochondrial) is an essential human protein that plays two key roles in mitochondrial DNA (mtDNA) homeostasis. TFAM acts as a transcription factor that specifically binds to promoter regions, but it is also solely responsible for organizing mtDNA into nucleoids by nonspecifically covering the entire genome. Many studies have addressed TFAM in transcription regulation, but its role as...

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Literature Corpus work: 4f04e668-2f25-5355-a697-f79e229b8c49
DOI: 10.64898/2026.04.24.720727

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