Article

Single-nucleoid imaging in whole cells defines the dynamics of the mtDNA life cycle

2026-06-03

Abstract excerpt

The mitochondrial genome (mtDNA) is essential for oxidative phosphorylation, and mammalian cells typically contain hundreds or thousands of copies. Although specific aspects of mtDNA replication and degradation have been explored, a complete account of the mtDNA life cycle has remained elusive, particularly for nondividing cells. Using super-resolution and 4D lattice light-sheet imaging, we quantified the full mtD...

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Literature Corpus work: ab84bab4-69b6-5deb-b665-32ee1a7d11d1
DOI: 10.64898/2026.06.01.725017

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