Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels.

Cell reports - 23 Nov 2021

Brüser Christian, Keller-Findeisen Jan, Jakobs Stefan

Abstract excerpt

In human cells, generally a single mitochondrial DNA (mtDNA) is compacted into a nucleoprotein complex denoted the nucleoid. Each cell contains hundreds of nucleoids, which tend to cluster into small groups. It is unknown whether all nucleoids are equally involved in mtDNA replication and transcription or whether distinct nucleoid subpopulations exist. Here, we use multi-color STED super-resolution microscopy to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to DNA, Mitochondrial
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Microscopy

Share to Mitochondria

Share to Mitochondrial Proteins

Share to Nucleoproteins

Source

Identifiers

PMID: 34818548
DOI: 10.1016/j.celrep.2021.110000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels.PMID 34818548Read ↗

Single-nucleoid imaging in whole cells defines the dynamics of the mtDNA life cycleSemantic proximity Read ↗

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid.Semantic proximity Read ↗

Organization and dynamics of human mitochondrial DNA.Semantic proximity Read ↗

Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation.Semantic proximity Read ↗

TFAM organizes DNA into compact higher order structuresSemantic proximity Read ↗

Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imagingSemantic proximity Read ↗

Transcription-dependent phase coexistence of mitochondrial nucleoids and RNA granulesSemantic proximity Read ↗

MitoPerturb-Seq identifies common and gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmySemantic proximity Read ↗

MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy.Semantic proximity Read ↗

Mitochondrial fission is required for proper nucleoid distribution within mitochondrial networksSemantic proximity Read ↗

Replication and Transcription of Human Mitochondrial DNA.Semantic proximity Read ↗

Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.