Article

Retinoid X Receptor Signaling Mediates Cancer Cell Lipid Metabolism in the Leptomeninges

2024-10-15

Abstract excerpt

<h4>Summary</h4> Cancer cells metastatic to the leptomeninges encounter a metabolically-challenging extreme microenvironment. To understand adaptations to this space, we subjected leptomeningeal-metastatic (LeptoM) mouse breast and lung cancers isolated from either the leptomeninges or orthotopic primary sites to ATAC-and RNA-sequencing. When inhabiting the leptomeninges, the LeptoM cells demonstrated transcripti...

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Identifiers and source

Literature Corpus work: c132fb07-e01d-522e-ab1d-6516bffea998
DOI: 10.1101/2024.10.13.618083

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