Article

LDHA-Dependent Aerobic Glycolysis Shapes Pro-fibrotic Myeloid Cell Fate through Histone Lactylation

2026-02-25

Abstract excerpt

<title>Abstract</title> <p>Metabolic reprogramming is a fundamental determinant of immune cell fate and effector function during inflammation, yet how distinct metabolic pathways regulate pathogenic lung macrophage activity and contribute to fibrotic remodeling remains incompletely understood. Here, we integrated single-cell RNA sequencing, lineage-specific genetic mouse models, and fate-mapping approaches to def...

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Literature Corpus work: c0bded72-66d0-52e4-8c7f-e3dd853cdfa0
DOI: 10.21203/rs.3.rs-8834018/v1

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