Article

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in <i>Drosophila</i>

2025-04-05

Abstract excerpt

Tumors reprogram lipid metabolism in distant tissues to support their growth. In adult Drosophila , gut tumors secrete the PDGF/VEGF-like factor Pvf1, which activates the TORC1-Hnf4 pathway in hepatocyte-like oenocytes. This drives production of very long-chain fatty acids and wax esters essential for tracheal growth around the tumor. Blocking Hnf4 or the elongase mElo in oenocytes strongly suppresses tracheogene...

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Literature Corpus work: 00a098e1-b8be-5bf0-97c9-12d13a59a637
DOI: 10.1101/2025.04.04.647255

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