Article

FASN Inhibition Resensitizes Chordoma to Radiotherapy by Targeting Adaptive Unsaturated Fatty Acid Metabolism

2026-05-14

Abstract excerpt

<h4>SUMMARY</h4> Chordoma, a rare malignant notochordal tumor of the skull base and spine, is typically resistant to chemotherapy and radiotherapy and exhibits aggressive local recurrence. Here we show that chordoma recurrence correlates with a coordinated upregulation of monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs), a low PFA/MUFA ratio and an adaptive, lipid peroxidation-resistant...

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Literature Corpus work: 6dba6a57-96fa-5a39-bd3e-26a247e4e79b
DOI: 10.64898/2026.05.11.724415

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