Article

Circadian Disruption Drives Extracellular Matrix Remodeling to Facilitate Pulmonary Metastatic Colonization

2026-04-23

Abstract excerpt

<h4>SUMMARY</h4> Circadian clocks impose temporal architecture on signaling networks, and disruption of this architecture predisposes to cancer metastasis. Through direct pharmacological and genetic perturbation of core clock components, we establish that circadian desynchronization in mouse lung fibroblasts eliminates temporal migration gating, creating constitutive motility responses to TNF-α and TGF-β, and ide...

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Literature Corpus work: 33f6beb6-32ae-5e3b-b4f2-a98dd25863d9
DOI: 10.64898/2026.04.20.719725

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