Article
Leptomeningeal metastatic cells adopt two phenotypic states.
Cancer reports (Hoboken, N.J.) - 1 Apr 2022
Remsik Jan, Chi Yudan, Tong Xinran, Sener Ugur, Derderian Camille, Park Abigail, Saadeh Fadi, Bale Tejus, Boire Adrienne
Abstract excerpt
BACKGROUND: Leptomeningeal metastasis (LM), or spread of cancer cells into the cerebrospinal fluid (CSF), is characterized by a rapid onset of debilitating neurological symptoms and markedly bleak prognosis. The lack of reproducible in vitro and in vivo models has prevented the development of novel, LM-specific therapies. Although LM allows for longitudinal sampling of floating cancer cells with a spinal tap,...
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