Article

Epigenetic reprogramming of melanoma cell state through fatty acid β-oxidation and Toll-like receptor 4 signaling

2022-06-17

Abstract excerpt

<h4>Summary</h4> Tumor cells respond to a host of factors from the local microenvironment. Microenvironmental fatty acids can be used by melanoma cells for fuel, but their effects on transcription and epigenetics are still unclear. Here, we show that the fatty acid β-oxidation (FAO) pathway integrates signaling and epigenetics to drive melanoma progression. Using transgenic zebrafish and human cell lines, we find...

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Literature Corpus work: 1accb3c9-f9ea-5f16-9f72-f518beb53e68
DOI: 10.1101/2022.06.16.496450

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