Article

Dynamic oncogene activity metabolically reprograms the tryptophan– kynurenine–AHR axis driving immune evasion and tumor progression in Ewing sarcoma

2025-05-21

Abstract excerpt

<h4>ABSTRACT</h4> The extent to which dynamic changes in oncogene activity shape cancer cell metabolism and drive disease progression remains poorly understood. Ewing sarcoma (EwS), driven by EWSR1::ETS fusion transcription factors, constitutes an ideal model to interrogate this question, as fluctuations in fusion activity direct divergent transcriptional programs. While EWSR1::ETS-high cells display a rather ses...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 57f9ab6d-33d2-552a-ba4d-9cd840d62036
DOI: 10.1101/2025.05.16.654502

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamic oncogene activity metabolically reprograms the tryptophan– kynurenine–AHR axis driving immune evasion and tumor progression in Ewing sarcomaDOI 10.1101/2025.05.16.654502Read

Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulationSemantic proximity Read

Neuroblastoma formation requires unconventional CD4 T cells and myeloid amino acid metabolismSemantic proximity Read

Novel Targeted Therapeutic Strategies for Ewing SarcomaSemantic proximity Read

Physiologically refined cell culture conditions uncover oncogene-dependent metabolic signatures in Ewing sarcoma spheroidsSemantic proximity Read

Integrative Multi-Omics and Single-Cell Analyses Reveal that Polyamine Metabolic Reprogramming Shapes an Immunosuppressive Microenvironment and Identifies ZWINT as a Prognostic Biomarker and Therapeutic Target in Lung AdenocarcinomaSemantic proximity Read

Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan MetabolismSemantic proximity Read

Refined culture conditions with increased physiological relevance uncover oncogene-dependent metabolic signatures in Ewing sarcoma spheroidsSemantic proximity Read

The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It ComplicatedSemantic proximity Read

Targeting the kynurenine pathway: another therapeutic opportunity in the metabolic crosstalk between cancer and immune cellsSemantic proximity Read

EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing SarcomaSemantic proximity Read

Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1Semantic proximity Read

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic TransformationSemantic proximity Read