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Article

Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis

14 Jul 2023

Abstract excerpt

Mammalian retinal metabolism favors aerobic glycolysis. However, the role of glycolytic metabolism in retinal morphogenesis remains unknown. We report that aerobic glycolysis is necessary for the early stages of retinal development. Taking advantage of an unbiased approach that combines the use of eye organoids and single-cell RNA sequencing, we identify specific glucose transporters and glycolytic genes in...

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PMID: 37452018
DOI: 10.1038/s41467-023-39672-2

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