Article

Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state

2023-05-10

Abstract excerpt

<h4>Summary</h4> More than half of all brain tumour survivors experience debilitating and often progressive cognitive decline after treatment with radiotherapy. Microglia, the resident macrophages in the brain, have been implicated in this decline. In response to various insults microglia can develop innate immune memory (IIM), which can either enhance (priming) or repress (tolerance) the response to subsequent i...

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Literature Corpus work: c1308440-9a60-58cd-bc85-4f7b65164ac7
DOI: 10.1101/2023.05.10.539581

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