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Article

Neuroprotective Effect of Fractalkine on Radiation-induced Brain Injury Through Promoting the M2 Polarization of Microglia.

Molecular neurobiology - 1 Mar 2021

Wang Jiaojiao, Pan Huijiao, Lin Zhenyu, Xiong Chunjin, Wei Chunhua, Li Huanhuan, Tong Fan, Dong Xiaorong

Abstract excerpt

Radiation-induced brain injury (RIBI) is a serious complication in cancer patients receiving brain radiotherapy, and accumulating evidence suggests that microglial activation plays an important role in its pathogenesis. Fractalkine (FKN) is a crucial mediator responsible for the biological activity of microglia. In this study, the effect of FKN on activated microglial after irradiation and RIBI was explored and...

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Identifiers

PMID: 33089423
DOI: 10.1007/s12035-020-02138-3
PMCID: PMC7878270

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