Article

CSF1R inhibition during cranial radiotherapy reshapes glial dynamics via microglial loss, monocyte engraftment, and accelerated astrocyte reactivity

2025-10-13

Abstract excerpt

<h4>Background</h4> Cranial radiotherapy (cRT), a common treatment for central nervous system tumors, induces progressive cognitive problems in over half of patients. In mice, microglial depletion via CSF1R inhibition can mitigate this effect, but the underlying cellular mechanisms remain unclear. We hypothesized that CSF1R inhibition-induced microglial ablation and repopulation improves brain health by modulatin...

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Literature Corpus work: 705a1641-3947-5e83-90c6-76db6ea942f7
DOI: 10.1101/2025.10.11.681366

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