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Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

1 Nov 2016

Abstract excerpt

Extensive transcriptional and ontogenetic diversity exists among normal tissue-resident macrophages, with unique transcriptional profiles endowing the cells with tissue-specific functions. However, it is unknown whether the origins of different macrophage populations affect their roles in malignancy. Given potential artifacts associated with irradiation-based lineage tracing, it remains unclear if...

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PMID: 27840052
DOI: 10.1016/j.celrep.2016.10.052

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