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Article

Low-Dose Ionizing Radiation Modulates Microglia Phenotypes in the Models of Alzheimer's Disease.

International journal of molecular sciences - 25 Jun 2020

Kim Sujin, Chung Hyunju, Ngoc Mai Han, Nam Yunkwon, Shin Soo Jung, Park Yong Ho, Chung Mi Joo, Lee Jong Kil, Rhee Hak Young, Jahng Geon-Ho, Kim Youngkyong, Lim Yu Jin, Kong Moonkyoo, Moon Minho, Chung Weon Kuu

Abstract excerpt

Alzheimer's disease (AD) is the most common type of dementia. AD involves major pathologies such as amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. During the progression of AD, microglia can be polarized from anti-inflammatory M2 to pro-inflammatory M1 phenotype. The activation of triggering receptor expressed on myeloid cells 2 (TREM2) may result in microglia phenotype switching from M1 to M2,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32630597
DOI: 10.3390/ijms21124532
PMCID: PMC7353052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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