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Article

Synthesis and Analysis of Bacterial Folate Metabolism Intermediates and Antifolates.

Organic letters - 6 Oct 2017

Dawadi Surendra, Kordus Shannon L, Baughn Anthony D, Aldrich Courtney C

Abstract excerpt

The mechanism of action of para-aminosalicylic acid (PAS), a drug used to treat drug-resistant tuberculosis (TB), has been confirmed through the first synthesis and biochemical characterization of its active metabolite 7. The synthesis features the coupling of N2-acetyl-6-formylpterin obtained from the degradation of folic acid and appropriately functionalized arylamines to form Schiff bases. The sequential...

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Identifiers

PMID: 28926267
DOI: 10.1021/acs.orglett.7b02487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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