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<i>Mycobacterium tuberculosis</i> sulfolipid-1 (Sl-1) increases the excitability of mouse and human TRPV1-positive sensory neurons in a YM254890-reversible fashion

2025-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Cough is a hallmark sign of tuberculosis and key driver of transmission. While traditionally attributed to host-driven inflammation, we previously demonstrated that Mycobacterium tuberculosis lipid extract (Mtb extract) and its component sulfolipid-1 (SL-1) directly activate nociceptive neurons to induce cough in guinea pigs. However, the cellular mechanisms by which Mtb extract and SL-1 modula...

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Literature Corpus work
6e917b45-c8a2-5e74-b0c2-fca8e4d17faf
DOI
10.1101/2025.06.28.662105
Open publication

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<i>Mycobacterium tuberculosis</i> sulfolipid-1 (Sl-1) increases the excitability of mouse and human TRPV1-positive sensory neurons in a YM254890-reversible fashionDOI 10.1101/2025.06.28.662105
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