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Anti-cancer drug Tamoxifen interferes with <i>Mycobacterium tuberculosis</i> PhoPR mediated signaling and inhibits mycobacterial growth

2023-12-19

Abstract excerpt

Two-component signaling (TCS) systems empower all bacteria, including intracellular pathogens like Mycobacterium tuberculosis (M. tb) to regulate key pathways governing growth, physiology and virulence. Amongst all M. tb TCS systems, PhoPR and DevRS have been studied extensively for their roles in regulating persistence and virulence. Here, we report that besides its cognate response regulator PhoP, the PhoR sen...

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Identifiers and source

Literature Corpus work
35b727b1-b47d-50fb-b8f0-07cab3ab8637
DOI
10.1101/2023.12.19.571805
Open publication

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Anti-cancer drug Tamoxifen interferes with <i>Mycobacterium tuberculosis</i> PhoPR mediated signaling and inhibits mycobacterial growthDOI 10.1101/2023.12.19.571805
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