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Article

A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.

Nature medicine - 1 Aug 2008

Vandal Omar H, Pierini Lynda M, Schnappinger Dirk, Nathan Carl F, Ehrt Sabine

Abstract excerpt

Acidification of the phagosome is considered to be a major mechanism used by macrophages against bacteria, including Mycobacterium tuberculosis (Mtb). Mtb blocks phagosome acidification, but interferon-gamma (IFN-gamma) restores acidification and confers antimycobacterial activity. Nonetheless, it remains unclear whether acid kills Mtb, whether the intrabacterial pH of any pathogen falls when it is in the...

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Identifiers

PMID: 18641659
DOI: 10.1038/nm.1795
PMCID: PMC2538620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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