Article

Promoter-intrinsic and local chromatin features determine gene repression in lamina-associated domains

2018-11-06

Abstract excerpt

It is largely unclear whether genes that are naturally embedded in lamina associated domains (LADs) are inactive due to their chromatin environment, or whether LADs are merely secondary to the lack of transcription. We show that hundreds of human promoters become active when moved from their native LAD position to a neutral context in the same cells, indicating that LADs form a repressive environment. Another set...

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Literature Corpus work: 412206d9-a77c-52da-8eb5-49d739aba8b1
DOI: 10.1101/464081

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