Article

Recapitulation of human germline coding variation in an ultra-mutated infant leukemia

2018-01-16

Abstract excerpt

<h4>Background</h4> Mixed lineage leukemia/Histone-lysine N-methyltransferase 2A gene rearrangements occur in 80% of infant acute lymphoblastic leukemia, but the role of cooperating events is unknown. While infant leukemias typically carry few somatic lesions, we identified a case with over 100 somatic point mutations per megabase and here report unique genomic-features of this case. <h4>Results</h4> The patien...

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Literature Corpus work: c108cef7-b761-5bec-803f-0bca6a59c1cd
DOI: 10.1101/248690

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