Article
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.
Nature medicine - 1 Jan 2018
Bolouri Hamid, Farrar Jason E, Triche Timothy, Ries Rhonda E, Lim Emilia L, Alonzo Todd A, Ma Yussanne, Moore Richard, Mungall Andrew J, Marra Marco A, Zhang Jinghui, Ma Xiaotu, Liu Yu, Liu Yanling, Auvil Jaime M Guidry, Davidsen Tanja M, Gesuwan Patee, Hermida Leandro C, Salhia Bodour, Capone Stephen, Ramsingh Giridharan, Zwaan Christian Michel, Noort Sanne, Piccolo Stephen R, Kolb E Anders, Gamis Alan S, Smith Malcolm A, Gerhard Daniela S, Meshinchi Soheil
Abstract excerpt
We present the molecular landscape of pediatric acute myeloid leukemia (AML) and characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The COG-National Cancer Institute (NCI) TARGET AML initiative assessed cases by whole-genome, targeted DNA, mRNA and microRNA sequencing and CpG methylation profiling. Validated DNA variants corresponded to diverse, infrequent mutations, with fewer...
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