Article
Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.
Nature cancer - 1 Feb 2023
Thatikonda Venu, Islam S M Ashiqul, Autry Robert J, Jones Barbara C, Gröbner Susanne N, Warsow Gregor, Hutter Barbara, Huebschmann Daniel, Fröhling Stefan, Kool Marcel, Blattner-Johnson Mirjam, Jones David T W, Alexandrov Ludmil B, Pfister Stefan M, Jäger Natalie
Abstract excerpt
Analysis of mutational signatures can reveal underlying molecular mechanisms of the processes that have imprinted the somatic mutations found in cancer genomes. Here, we analyze single base substitutions and small insertions and deletions in pediatric cancers encompassing 785 whole-genome sequenced tumors from 27 molecularly defined cancer subtypes. We identified only a small number of mutational signatures...
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