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Article

Developmental timing of mutations revealed by whole-genome sequencing of twins with acute lymphoblastic leukemia.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013

Ma Yussanne, Dobbins Sara E, Sherborne Amy L, Chubb Daniel, Galbiati Marta, Cazzaniga Giovanni, Micalizzi Concetta, Tearle Rick, Lloyd Amy L, Hain Richard, Greaves Mel, Houlston Richard S

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the major pediatric cancer. At diagnosis, the developmental timing of mutations contributing critically to clonal diversification and selection can be buried in the leukemia's covert natural history. Concordance of ALL in monozygotic, monochorionic twins is a consequence of intraplacental spread of an initiated preleukemic clone. Studying monozygotic twins with ALL provides a...

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Identifiers

PMID: 23569245
DOI: 10.1073/pnas.1221099110
PMCID: PMC3645544

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Source receipt: pubmed, retrieved 7 Sept 2026.

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