Article
Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report.
Leukemia - 1 Jun 2014
Valentine M C, Linabery A M, Chasnoff S, Hughes A E O, Mallaney C, Sanchez N, Giacalone J, Heerema N A, Hilden J M, Spector L G, Ross J A, Druley T E
Abstract excerpt
Infant leukemia (IL) is a rare sporadic cancer with a grim prognosis. Although most cases are accompanied by MLL rearrangements and harbor very few somatic mutations, less is known about the genetics of the cases without MLL translocations. We performed the largest exome-sequencing study to date on matched non-cancer DNA from pairs of mothers and IL patients to characterize congenital variation that may...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.