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Article

A high proportion of germline variants in pediatric chronic myeloid leukemia.

Molecular cancer - 26 Sept 2024

Krumbholz Manuela, Dolnik Anna, Sträng Eric, Ghete Tabita, Skambraks Sabrina, Hutter Stephan, Simonis Alfred, Stegelmann Frank, Suttorp Meinolf, Horn Anselm H C, Sticht Heinrich, Haferlach Torsten, Bullinger Lars, Metzler Markus

Abstract excerpt

Chronic myeloid leukemia (CML) typically occurs in late adulthood. Pediatric CML is a rare form of leukemia. In all age groups, the characteristic genetic driver of the disease is the BCR::ABL1 fusion gene. However, additional genomic events contribute to leukemic transformation, which is not yet well-characterized in pediatric CML. We investigated the mutational landscape of pediatric CML to determine whether...

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Share to Germ-Line Mutation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fusion Proteins, bcr-abl

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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Source

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Identifiers

PMID: 39327604
DOI: 10.1186/s12943-024-02109-5
PMCID: PMC11426096

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